Multi-component Process for the Synthesis of Some Phosphonate Derivatives using Water as a Green Solvent

Three-component Process for the Synthesis of Some Substituted Pyrroles using Water as a Green Solvent

A novel, convenient and efficient three-component reaction for synthesizing substituted pyrroles from primary amines and electron deficient acetylenic compounds in the presence of ammonium thiocyanate in water leads to the formation of pyrroles in good yields.

Three-component Process for the Synthesis of Some Thiophene Derivatives Using Water as a Green Media

A convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields.

three-component process for the synthesis of some substituted pyrroles using water as a green solvent

Synthesis of Thiazole Derivatives via Multicomponent Reaction of Tetramethyl thiourea using Water as a Safe Solvent

An efficient synthesis of 1,3-thiazole drivatives is described via a three component reaction isothiocyanates, tetramethyl thiourea and ethyl bromopyruvate.

One-pot Three-component Synthesis of Phosphonate Derivatives

The stable phosphonate derivatives have easily synthesized by the reactions involving trialkyl(aryl) phosphites and dimethyl acetylenedicarboxylate in the presence of 4-nitrophenol and/or acid chlorides, dialkyl(aryl) phosphites and N-methylimidazole at 70 oC under solventfree conditions.

Water as the Green Media for the Synthesis of Isoquinoline Derivatives

An efficient synthesis of isoquinoline-2,3-dicarboxylates is described via one-pot reactions of isoquinoline and alkyl bromids with dialkyl acetylenedicarboxylates in water at 70oC. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.